Text Readings in Lewis
Chapters 13 - 16 Review It Can't Be! pgs 362 and 281 Using Human Genome Information, pgs 302-303 From Genetics to Biotechnology, pgs 334-335 Genes To The Rescue, pgs 326 and 345

The text book has limited information concerning the topic of biotechnology so I have tried to provide web links that should provide the needed background information. I hope you find them to be interesting and understandable. We will supplement this information with activities in lab and discussion to help you understand biotechnology.

For feedback, post possible answers and ideas in the folder"Text 'Review' and 'To Think About' Questions" in the Biology Chat Section of Web Crossing.

Objectives
After studying this material you should be able to:

1. Describe the inheritance of a mutation that results in the manifestation of a genetic disorder. Describe the roles of DNA and proteins in such a disorder.

2. Describe the goals of the Human Genome Project and and the relationship of the project to the understanding of genetic diseases.

3. List and explain in general terms the three questions that must be answered in an attempt to prevent or treat a genetic disorder.

4. Explain in general terms the goals of and concerns about somatic gene therapy.

5. Discuss the issues involved in the use of gene testing to identify a potential genetic disorder.

6. Define biotechnology in its broad and narrow sense.

7. Describe the general goals of biotechnology

Web resources:

These sites contain a wealth of information concerning genetics, DNA, and Biotechnology. I will include links to specific topics in the body of the outlines for this lecture and lectures 18 and 19, however I invite you to explore on your own. There might be potential net surfer projects here.

• From Maps to Medicine: About the Human Genome Research Project

• Understanding Gene Testing
  U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
  Public Health Service National Institutes of Health National Cancer Institute
  Accessed from Access Excellence a web site managed by Genentech, a biotechnology company in California

• Access Excelence Graphics Gallery

• Principles Of Biotechnology North Central Regional Extension Publication Iowa State University - University Extension

• Biotechnology - The Future from Access Excellence

• The Washington Biotechnology Action Council This organization provides an alternative view of the potential benefits of biotechnology

• See Lewis' Text page 338-339

• Inheritance of Autosomal Recessive Trait

• Gene Expression & the Role of Proteins
  • How are genes linked to disease?

  • How does a faulty gene trigger disease?

  • How do gene mistakes occur?

The Human Genome Project

The Human Genome Project (History & Mission)

Goals of the Human Genome Project:

• to construct detailed genetic and physical maps of the human genome,

• to determine the complete nucleotide sequence of human DNA,

• to localize the estimated 50,000-100,000 genes within the human genome,

• and to perform similar analyses on the genomes of several other organisms used extensively in research laboratories as model systems.

• How to Conquer A Genetic Disease

• Lactose Intolerance

• Somatic gene Therapy

• See also Lewis, Genes To The Rescue, pgs 326 and 345, gene therapy for ADA deficiency.

• CF GENE THERAPY BEGINS By Sean Henahan, Access Excellence

• Pioneer James Wilson Reflects On Gene Therapy's Hopes, Hype

• What is gene testing?

• What are the uses of genetic testing?

• What are the benefits of gene testing?

• What are the limitations of gene testing?

• What are the risks of gene testing?

• Principles of Biotechnology North Central Regional Extension Publication Iowa State University - University Extension

Biotechnology - The Future from Access Excellence

Take me home.