Biology 100/101
Lecture 15: Mutation
Lecture Activity Summary

Point mutations - changes in single DNA nucleotides.

Part of gene
to be transcribed		 CTG / TTA / CGC
mRNA
transcribed
from DNA		 GAC / AAU / GCG Protein
translated
from mRNA		 Asp / Asn / Ala
Mutation 1 CTG /TTG / CGC Silent mRNA
transcribed
from DNA		 GAC / AAC / GCG Protein
translated
from mRNA		 Asp / Asn / Ala
Mutation 2CTG /TTT / CGC Missense mRNA
transcribed
from DNA		 GAC / AAA / GCG Protein
translated
from mRNA		 Asp / Lys / Ala
Mutation 3ATT /TTA / CGC Nonsense mRNA
transcribed
from DNA		 UAA / AAU / GCG Protein
translated
from mRNA		 STOP

Frameshift mutations: Additions or Deletions of one or more nucleotides.

Part of gene
to be transcribed		 CTG / TTA / CGC
mRNA
transcribed
from DNA		 GAC / AAU / GCG Protein
translated
from mRNA		 Asp / Asn / Ala
Mutation 1 CTA / GTT / ACG / C Addition mRNA
transcribed
from DNA		 GAU / CAA / UGC / G?? Protein
translated
from mRNA		 Asp / Gln / Cys / 1 of 5?
Mutation 2 CT_T / TAC / GC Deletion mRNA
transcribed
from DNA		 GA_A / AUG / CG? Protein
translated
from mRNA		 Glu / Met / Arg
Mutation 3 CTG / CTG / TTA / CGC Expansion mRNA
transcribed
from DNA		 GAC / GAC / AAU / GCG Protein
translated
from mRNA		 Asp / Asp /Asn / Ala

Lecture Syllabus.