Ph: (217) 333 1630, FAX: (217) 244 6615, E-Mail: biophysics@life.uiuc.edu
Director: Martin Gruebele Administrative Coordinator: Cindy Dodds
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The elucidation of multifarious molecular structures, conformational changes, thermodynamic stabilities and functions of nucleic acids and protein/nucleic acid complexes is a major research topic in our laboratory. We employ a variety of techniques, such as fluorescence spectroscopy, rapid kinetic methods and physical perturbations in order to probe the intra- and intermolecular interactions of these macromolecular structures, and to understand the physical basis of their biological functions. Modern biotechnology makes it possible to synthesize tailored molecules that represent many aspects of the natural bio-molecular systems, and permits us to relate our physical measurements to specific selected characteristics of biological systems. |
