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Ido Golding Assistant Professor of Physics and Biophysics Ph.D. 2002, Tel Aviv University, Israel Systems Biology: The study of intracellular dynamics with single-event resolution Ido Golding 315 Loomis, MC-704 1110 W. Green Urbana, IL 61801 217-244-4775 igolding@uiuc.edu

I study the E. coli bacterium and its virus, the bacteriophage lambda. These two organisms serve as basic paradigms for many physiological processes, including gene expression, epigenetic stability and switching, viral-host interactions, DNA replication, genetic recombination and more. I have developed and applied new quantitative tools for probing cellular interactions within these systems by combining genetic manipulation and high sensitivity fluorescence imaging. This strategy allows us to follow dynamic processes in individual cells, in real time, with a single-event resolution. In my lab, such quantitative experimental work will be accompanied by mathematical modeling, with a constant feedback between the two endeavors.

The work employs a set of skills broader than those generally mastered within a single discipline, including the techniques of microbiology and molecular genetics, real-time imaging of live cells to make dynamic measurements, and data analysis using the engineer's toolbox of signal and image processing, all accompanied by the theoretical tools of dynamical systems theory, stochastic processes, non-equilibrium phenomena and more. As such, this practice of modern in vivo biology, combined with the high intellectual effort of a quantitative approach, will contribute significantly to a young scientist's training experience, better preparing them for the future world of "Systems Biology".