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CMB faculty have primary or secondary appointments in eleven departments and four interdepartmental research programs on campus. The CMB Training Program therefore draws together researchers from across the campus with common research interests in modern cell and molecular biology. This provides for an exciting and highly collaborative training environment for graduate students. The current CMB training faculty are listed below, along with their departmental affiliations and a brief summary of their research interests.

Milan K. Bagchi, Molecular & Integrative Physiology: Transcriptional regulation by steroid & thyroid hormone receptors; mechanisms of coactivators

Janice M. Bahr, Animal Sciences, Molecular & Integrative Physiology: Avian infectious bronchitis virus—impact on fertility; ovarian cancer

Jonathan E. Beever , Animal Sciences, Swine genomics

Andrew S. Belmont, Cell & Developmental Biology: Chromatin structure; nuclear architecture; control of gene expression

May R. Berenbaum, Entomology: Chemical interactions between herbivorous insect & host plants

Philip M. Best, Molecular & Integrative Physiology: Calcium channels in the heart: structure, function & regulation

Stephanie S. Ceman, Cell & Developmental Biology, College of Medicine: RNA-protein interactions and regulation of RNA expression in Fragile X syndrome; molecular basis for disease

Jie Chen, Cell & Developmental Biology: Signal transduction in mammalian cell growth & differentiation; rapamycin-sensitive signaling network

Charles L. Cox, Molecular & Integrative Physiology; Biophysics, Neurobiology : Neuromodulation of thalamocortical circuits, neuronal excitability, synaptic physiology, epilepsy

John E. Cronan, Jr., Microbiology; Biochemistry: Biosynthesis, regulation & function of membrane lipids & fatty acid-derived coenzymes

Brian C. Freeman, Cell & Developmental Biology: Nuclear protein complexes; gene regulation; molecular chaperone action & disassembly of nuclear protein complexes

Jeffrey F. Gardner, Microbiology: Mechanisms of site-specific recombination by phage & transposons; recognition of DNA by proteins

Robert B. Gennis, Biochemistry; Chemistry; Biophysics: Membrane enzymes involved in energy transduction; electron transport chains

Julia M. George, Molecular & Integrative Physiology: Synuclein proteins and neurodegenerative disease

John A. Gerlt, Biochemistry: Evolution of enzyme superfamilies; mechanisms of enzyme catalysis; functional genomics

Martha Gillette, Cell & Developmental Biology: Cellular & molecular mechanisms of circadian rhythms in mammalian brain; molecular gating of signal transduction

William T. Greenough, Psychology; Cell & Developmental Biology; Bioengineering, Director, Center for Advanced Study: Mechanisms at the cellular and system level whereby the nervous system stores information; memory; blood vessels in brain; fragile X

Jonathan J. Henry, Cell & Developmental Biology: Mechanisms of cell determination in Xenopus; development of the vertebrate lens

Paul J. Hergenrother, Chemistry, Biochemistry: Using small molecules to modulate programmed cell death; Identification and use of compounds with novel anti-cancer, anti-neurodegenerative, and anti-bacterial properties

Raven H. Huang, Biochemistry, Biophysics: Molecular recognition and mechanisms of enzymes involved in tRNA modifications; structural studies of enzymes bound to RNA substrates

James A. Imlay, Microbiology: Molecular mechanisms of oxidative damage; cellular defenses against oxidants; obligate anaerobiosis

Joan S. Jorgensen, Veterinary Bioscience: Role of specific genes in determining embryonic development of male & female gonads

Benita Katzenellenbogen, Cell & Developmental Biology, Molecular & Integrative Physiology: Regulation of gene expression, signal transduction & cell proliferation by hormones & growth factors; mechanisms of hormone/antihormone action in normal and cancer cells

Neil L. Kelleher, Chemistry: Enzymology and “Top Down” proteomics: translating Fourier-transform mass spectrometry into biological insight

Byron W. Kemper, Cell & Developmental Biology, Molecular & Integrative Physiology: Regulation of P450 gene expression; structural basis for cellular localization, membrane association, assembly, and substrate interaction of P450

David M. Kranz, Biochemistry: Structure, function, and engineering of T cell receptors; molecular basis of immune recognition and autoimmune diseases; tumor targeting with bispecific agents

Andrei Kuzminov, Microbiology: Chromosomal fragmentation: mechanisms, avoidance and repair

Kurt E. Kwast, Molecular & Integrative Physiology: Transcriptional regulation of oxygen-sensing genes; physiological genomics of oxygen regulation

Paul C. Lauterbur, Chemistry, Biophysics: Mechanisms by which molecular imprints may have been involved in the transition form chemistry to biology

Harris A. Lewin, Animal Sciences, Director, Institute for Genomic Biology: Bovine genomics; phylogenomics; immunogenetics of bovine leukemia virus

William Metcalf, Microbiology: Molecular genetics and biochemistry of methanogenic Archaea; redox cycling of phosphorus by microorganisms

Craig A. Mizzen, Cell & Developmental Biology: Chromatin structure, function and metabolism

James H. Morrissey, Biochemistry, College of Medicine: Regulation of cell-surface protease activity; mechanisms for modulating the blood coagulation and fibrinolytic enzyme cascades

Ann W. Nardulli, Molecular & Integrative Physiology: Regulation of estrogen- responsive genes.

Phillip A. Newmark, Cell & Developmental Biology: Planarian regulation, stem cell biology, germ line development

Romana A. Nowak, Animal Sciences: Regulation of trophoblast cell differentiation & implantation; women’s reproductive diseases

Gene E. Robinson, Entomology; Director, Neuroscience Program: Mechanisms of behavior in social insects; honeybee genomics

Christopher J. Schoenherr, Cell & Developmental Biology: Regulation of gene expression by chromatin; mechanisms of gene silencing and activation in genomic imprinting

Mary A. Schuler, Cell & Developmental Biology, Biochemistry, Plant Biology: Molecular biology, biochemistry and genomics: pre-mRNA processing and P450 monooxygenases

David Shapiro, Biochemistry: The molecular biology of estrogen receptor action

Joanna L. Shisler, Microbiology: Strategies human poxviruses utilize to evade the immune response; viral mechanisms to dampen inflammation

Scott K. Silverman, Chemistry; Biochemistry, Biophysics: DNA as an enzyme; DNA as a macromolecular structural constraint; RNA folding and catalysis; allosteric nucleic acid enzymes as sensors

James M. Slauch, Microbiology, College of Medicine, Director, Medical Scholars Program: Molecular mechanisms of Salmonella pathogenesis.

Stephen G. Sligar, Biochemistry, Chemistry, College of Medicine: Structural and functional characterization of macromolecular assemblies and the enzymes of biological oxidations, nano-scale systems for human therapeutics, genome/proteome analysis

Jonathan V. Sweedler, Chemistry, Director, Biotechnology Center: Application of microseparation, mass spectrometry, and bioinformatics to investigate signaling molecules in a range of nervous systems from mollusks and arthropods to vertebrates

Richard I. Tapping, Microbiology: The role of toll-like receptors in host innate immune defense

Willem A. Van der Donk, Chemistry, Biochemistry: Understanding enzymatic transformations of pharmaceutical importance; Lantiobiotic synthesis

Brenda A. Wilson, Microbiology: Bacterial protein toxins: interaction with host cells and effects on intracellular signal transduction; development of novel alterative anti-toxin therapeutics

Colin A. Wraight, Biochemistry, Plant Biology, Biophysics: Electron and proton transfer in proteins; molecular engineering of ligand-protein interactions

Huimin Zhao, Chemical & Biomolecular Engineering: Directed evolution of enzymes & biosynthetic pathways



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