Lecture 8The Proton Circuit |


Mitochondrial oxidative phosphorylation - the overall reactions and proton pumping stoichiometries of the complexes (for transfer of 2 electrons). The complexes are shown in their physiological state (as dimers for complexes II, III, and IV), and represented by their structures, approximately to scale. The structures for the crystallographically resolved complexes are show by their surfaces, made transparent so as to show the prosthetic groups. The following data sets were used: Complex II, 1fum; Complex III, 1bcc; Complex IV, 2occ; ATP synthase, 1qo1.
A Table showing membrane proteins for which crystallographic structures are curently available (from Martmut Michel's lab)