Structure of F1F0 ATP synthase from yeast mitochondria

In the initial view, the crystallographic structure is shown as a Ca-backbone, with the subunits colored by chain. The g-subunit projects from the cylinder formed by the 3 a, b-subunits at the bottom, which is the interface with Fo. The structure also contains the d-subunit, which is equivalent to the e-subunit in the E. coli nomenclature.

The protein, showing subunits

Click here to reset to original view, with backbone structure.

Views of F0

Click here to see a cross-section through F0. The blue spheres show the Ca-atoms of the conserved acidic side chain (aspartate in yeast), thought to be involved in the H+-turbine.

A canted view of the c-subunit ring. The Ca-atoms of the aspartate involved in the H+-turbine are in yellow

Reference

  1. Stock, D., Leslie, A.G.W. and Walker, J.E. (1999) Molecular architecture of the rotary motor in ATP synthase. Science 286, 1700-1705
©Copyright 1996, Antony Crofts, University of Illinois at Urbana-Champaign, a-crofts@uiuc.edu