selected publications
Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Gu, Y., Sasaki, T., Suzuki, A., Forrester, J. V., Bourne, H. R, Devreotes, P. N., McCaig, C. D., and Penninger, J.M. 2006. Electric signals control wound healing via phosphatidylinositol-3 kinase-gamma and PTEN. Nature, 442:457–60.
Xu, J., Wang, F.*, Van Keymeulen, A., Rentel, M., and Bourne, H. R. 2005. Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci USA, 102:6884–9.
Xu, J., Wang, F.*, Van Keymeulen, A., Herzmark, P., Straight, A., Kelly, K., Takuwa, Y., Mitchison, T., and Bourne, H. R. 2003. Divergent signals and cytoskeletal assemblies regulates self-organizing polarity in neutrophils. Cell, 114:201–14.
Srinivasan, S., Wang, F.*, Glavas, S., Ott, A., Hofmann, F., Aktories, K., Kalman, D., Hahn, K., and Bourne, H. R. 2003. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol, 160:375–85.
Wang, F., Herzmark, P., Weiner, O. W., Srinivasan, S., Servant G., and Bourne, H. R. 2002. The lipid products of PI3K maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol, 4:513–8.
Liu, H., Radisky, D. C., Wang, F., Bissell, M.J. (2004) PI3-kinase signaling integrates polarity and roliferation in human mammary epithelial cells cultured in three dimension. J Cell Biol, 164, 603–12.
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., and Bissell, M. J. (1997). Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol 137, 231–45.
Wang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., and Bissell, M. J. (1998). Reciprocal interactions between beta-1 integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in normal and malignant epithelial biology. Proc Natl Acad Sci U S A 95, 14821–26.
Wang, F., Hansen, R. K., Radisky, D., Petersen, O. W., Yoneda, T., Barcellos-Hoff, M. H., Turley, E. H., and Bissell, M. J. (2002). Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst 94, 1494–503.
* Co-first author