Click on the links below to download pdf versions of the lecture material.

Schedule

Syllabus

Introduction (Overview, Chapter 1)

Host defenses-1: Barriers (Chapter 4)

Host defenses-2: Innate Defenses (Chapter 5)

Host defenses-3: Adaptive Defenses (Chapter 6)

MeasuringVirulence (Chapters 2-3 + other material)

Mechanisms of Genetic Exchange (Chapters 2-3 + other material)

Identification of Virulence Factors (Chapters 2-3 + other material)

Virulence Factors-1: Adherence, Evasion & Dissemination (Chapters 8-11 + other material)

Virulence Factors-2: Toxins

Virulence Factors-3: Antibiotic Resistance

Vaccines (Chapter 7 + other material)

Delivery of Virulence Factors (Chapters 8-11 + other material)

Regulation of Virulence Factors-1: Gene Regulation (Chapters 8-11 + other material)

Regulation of Virulence Factors-2: Quorum Sensing

Toxin-mediated Disease: Diphtheria (Chapter 9 + other material)

Toxin-mediated Disease: Anthrax (Chapter 22 + other material)

Toxin-mediated Disease and Pathogen Evolution: Cholera (Chapter 25 + other material)

Intracellular Survival & Virulence Regulation: Salmonella (Chapter 26 + other material)

Salmonella Presentation by Guest Lecturer Dr. Slauch

Lessons from History: Yersinia, the Plague and Virulence Factor Delivery (Chapter 13)

Bioterrorism (Chapter 22 + other material, supplemental Chapter)

Invasion and Cell-to-Cell Spread: Listeria (Chapter 27)

Virotyping: Shigella & E. coli (Chapters 28-29 + other material)

Emerging and Re-emerging Pathogens: Staphylococci and Streptococci (Chapter 14, 15, 18)

Koch's Postulates & Stealth Pathogens: Helicobacter & Chlamydia (Chapters 21, 23, 31)

Lessons from History: Spirochetes & Ethics (Chapter 12)

Multidrug-Resistant Pathogens: Mycobacterium (Chapter 19)