Research Ethics and Responsibilities
(http://www.life.uiuc.edu/mcb/580/)

Molecular and Cellular Biology 580
University of Illinois at Urbana-Champaign
Spring 2008

Wednesdays
January 23 - March 5, 2008
7:00 - 9:50 pm
Chemical & Life Sciences Auditorium
(this differs from the Schedule of Classes)


Contents of This Page


Course Organization

Registration:

Title: Research Ethics and Responsibilities
Course Rubric:
MCB 580
Course Reference Number (CRN): 38677 (for 2008)
Prerequisite: Graduate standing in MCB or consent of instructor
Credit: 1 Hour Credit, S/U Grade Only
Time: Wednesday evenings 7:00-9:50 PM, January 23, 2008 through March 5, 2008

Place: Chemical and Life Sciences Auditorium

Instructors:

Gary Olsen gary@life.uiuc.edu Department of Microbiology, B103 C&LSL, MC-110
Stephen Farrand stephenf@life.uiuc.edu Department of Microbiology, B103 C&LSL, MC-110
Guest Lecturers (subject to change):
Bob Wengert
C. K. "Tina" Gunsalus
Irene Cooke
Janice Bahr
Lyndon Goodly
Required Text:
Macrina, F. 2005. Scientific Integrity, Third edition. American Society for Microbiology Press, Washington, D.C.

Course Format:

Most weeks class will be divided into two sessions covering different topics. A "typical" session will be:

Attendance is mandatory. If you are absent from a class, a make-up paper on the topics covered during the missed class will be required. Failure to make-up for a missed class by turning in the required paper or more than one absence will result in an unsatisfactory grade. (Because this is a short course, missing 2 weeks would mean missing nearly 30% of the material and discussion. We cannot excuse more than one absence.)

Make-up papers should be 5-7 pages (typed, double-spaced, 1 inch margins). The paper should focus on the topics missed, describing relevant issues, potential problems, and acceptable practices. The textbook and online materials should provide the background for the paper. All references used should be cited. (Think about it: this is an ethics course.) Following the discussion of the topics, the paper should apply the principles discussed to the case studies presented in the missed class (copies can be obtained from one of the course instructors). The paper should be of suitable clarity and perspective that it would provide a concise overview of the topics to a reader who is unfamiliar with the topics. The paper will be evaluated by the instructors, and if it is not of acceptable quality it will be returned to be rewritten.

Course Grades:
An S/U grade will be assigned based upon attendance, the in-class writing assignments, participation and completion of assigned on-line training.


Course Schedule (Spring 2008)

(subject to change)

January 23

  1. Introductory Comments (presentation as PDF) (Gary Olsen)

  2. Ethics (handout as PDF, which includes a questionnaire) (Bob Wengert)
    Macrina Chapter 2
    1. Ethics: What is it (and what is it not)
    2. Ethics versus morality
    3. Questionnaire on what is ethical versus not (or right versus wrong)

  3. Science and Society (presentation as PDF) (Gary Olsen)
    Macrina Chapters 1 and 2
    1. Scientific ethics
    2. Scientific integrity
    3. Scientific misconduct: Fabrication, falsification, or plagiarism (full definition)
    4. Fraud
    5. Social perspectives of science and scientists
    6. Responsibility of scientists to society (On Being a Scientist)
    7. Course Agreement (which must be turned in by all students)

January 30

  1. Dealing with Problems (C. K. "Tina" Gunsalus)
    1. Ethical research
    2. Academic misconduct
    3. How and where to report problems
    4. Who you can turn to for support, advice and help
    5. Harassment
    6. Questions and discussion

  2. Scientific Ethics in the News: Case 1 (Stephen Farrand)

  3. Homework: Complete (if necessary) your "General Lab Safety Training", and make a copy of the certificate for the Feb. 6 meeting (see details below).

February 6

  1. Laboratory Safety and Compliance (Irene Cooke)
    All students are required to take the University of Illinois at Urbana-Champaign Division of Research Safety "General Lab Safety Training".
    A copy of the certificate should be turned in by this (February 6) class meeting. Most of you will have already done this, so it is only necessary to print a copy of the certificate. Please make it a copy, we will not return them.
    1. Basic Laboratory Safety (HHMI)
    2. Biohazards (CDC)
    3. Recombinant DNA (NIH)
    4. Hazardous chemicals
    5. Transfer of etiologic agents
    6. Radioactivity (UIUC)
      • Safe handling of radioactive materials
      • Regulations

  2. Scientific Ethics in the News: Case 2 (Gary Olsen)

February 13

  1. Conflict of Interest and Conflict of Commitment (Janice Bahr)
    Macrina Chapters 7 and 9, and Appendix V
    1. Conflict of interest and conflict of commitment (UIUC)
      • Conflict of commitment - external activities that interfere with an individual's responsibility to the University
      • Conflict of interest - situations that may benefit an individual or the individual's family to the detriment of the University
      • Conflict of interest disclosure
    2. Intellectual property
      • Intangible - ideas, inventions, discoveries
      • Protections - patent, copyright, trademarks, etc.
      • Intellectual property rights (University of Illinois)
        • If conceived or developed by an employee or student during work or on University business - University retains ownership of inventions
        • Traditional academic work done independently on the individual's own initiative - individual retains ownership of copyright
        • Work done as part of assigned University duties - University retains ownership of copyright

February 20

  1. Scientific Communication (Stephen Farrand)
    Macrina Chapter 4
    1. Presenting your work: seminars and publications
    2. Allocation of credit
    3. Authorship

  2. The Results of Research: Notekeeping and other important issues (Stephen Farrand)
    Macrina Chapters 9 and 11, and Appendix VI
    1. Notekeeping
      • Verification
      • Repetition
    2. Data ownership
      • For federally funded research, the institution legally owns the data
      • Most responsibility for the data delegated to the Principal Investigator
    3. Legal ramifications - The Baltimore case
    4. Case study - Who owns the data?

  3. Homework: Complete the "Human Participant Protections Education for Research Teams", and make a copy of the certificate for the Feb. 27 meeting (see details below).

February 27

  1. Animal Use (and human subjects) (Lyndon Goodly)
    Macrina Chapters 5 and 6, and Appendix IV
    All students are required to complete the National Cancer Institute
    "Human Participant Protections Education for Research Teams"
    OR the NIH Office of Extramural Research "Protecting Human Research Participants".
    The NCI course was discontinued March 1, 2008. If you did not complete it, you must complete the new NIH course instead.
    A copy of the certificate should be turned in at this class meeting (February 27). Please make it a copy, we will not return them.
    1. Laboratory animals
    2. Human subjects (UIUC)
      • Informed consent
      • Institutional Review Boards (IRB)

  2. Grant proposals and Scientific Review (presentation as PDF) (Gary Olsen)
    Macrina Chapter 4
    1. Grant proposals
    2. Peer review of manuscripts
      • Editors
      • Ad hoc reviewers
    3. How ethical problems arise
      • Financial conflicts
      • Intellectual conflicts
      • Personal conflicts
      • Confidentiality

March 5

  1. Career Night: Options for your life with a degree
    • Guests:
    • Dr. Steven Sligar, Director, School of Molecular and Cellular Biology
    • Dr. Melanie Loots, Associate Vice Chancelor for Research


Some Useful Published Resources


Some Useful Internet Resources


This page is maintained by Gary Olsen. Please send any comments, suggestions or questions to: gary@life.uiuc.edu
Last modified February 13, 2008