The Faculty in Reproductive Biology at Illinois

Gary L. Jackson

Veterinary Biosciences
Ph.D., University of Illinois

To e-mail Dr. Jackson use: g-jackson@uiuc.edu

Research in my laboratory deals with two aspects of neuroendocrine control of gonadotropin and prolactin secretion. A major goal is to understand the relative roles of putative endogenous circannual oscillators, photorefractoriness, and photoinduction in regulating annual cycles of reproduction and prolactin secretion. Studies in sheep on the effects of photomanipulations, drugs, and hypothalamic lesions are in progress.

A second area of study is the relationship between gonadal steroids, neurotransmitters, and secretion of hypothalamic and pituitary hormones in response to environmental and physiological stimuli. The techniques of in situ hybridization, microinfusion, push-pull perfusion, and portal vessel cannulation are used to study temporal changes in secretion of hypothalamic compounds and pituitary hormones in sheep subjected to endocrine and environmental manipulations.

Selected Publications:

Jansen HT, Iwamoto GA, Jackson GL. 1998. Central connection of the olfactory bulb formation identified using wheatgerm agglutinin-conjugated horseradish peroxidase. Brain Res Bull 45:27-39.

Ferreira SA, Hileman SM, Kuehl DE, Jackson GL. 1998. Effects of dialyzing gamma-aminobutyric acid receptor antagonists into the medial preoptic and arcuate ventromedial region on luteinizing hormone release in male sheep. Biol Reprod 58:1038-1046.

Hileman SM, Kuehl DE, Jackson GL. 1998. Photoperiod affects the ability of testosterone to alter proopiomelanocortin mRNA, but not luteinizing hormone-releasing hormone mRNA, levels in sheep. J Neuroendocrinology 10:587-592.

Hileman SM, Handa RJ, Jackson GL. 1999. Distribution of estrogen receptor-ß mRNA in the male sheep hypothalamus. Biol Reprod 60:1279-1284.

Hileman SM, Jackson GL. 1999. Regulation of gonadotropin-releasing hormone secretions by testosterone in the ram. In: Thatcher WW, inskeep EK, Niswender GD, Doberska C (eds.). reproduction in Domestic Ruminants IV. J Reprod Fert Suppl 54:231-242.

Jackson GL, Wood SG, Kuehl DE. 2000. A GABA-b agonist reverses the negative feedback effect of testosterone on gonadotoropin releasing-hormone and luteinizing hormone secretion in the male sheep. Endocrinology 141:(in press).

Last updated August 25, 2000

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