Evolution and Development of Mammals

.

Research

    Evolution and development of mammals

 

Research in our lab is driven by our goal of understanding how developmental mechanisms influence morphologic diversification. To pursue our goal, we combine traditional embryological and paleontological approaches with modern developmental genetic and morphometric techniques to gather data from fossil and living mammals.  We study mammals because they not only possess a variety of developmental modes, adult morphologies and a good fossil record, but also include one of the best-studied model organisms – the mouse.  In addition to mouse, we utilize a variety of other mammalian species in our study of development, including bats, kangaroos, possums, artiodactyls and moles. 


Historically, our understanding of patterns of morphologic evolution has come from the comparative anatomical study of living organisms and those preserved as fossils. By applying data from additional sources, such as developmental genetics, to the study of morphologic evolution we are able to go a step further and examine the processes responsible for these patterns. This allows us to address large-scale questions such as how do: developmental changes lead to morphologic innovations, developmental mechanisms bias the direction of morphologic evolution, and different genetic mechanisms contribute to morphologic evolution?


Please click on the links below to get details on some of the research subjects pursued in the lab.

Mammalian limb evolution and development
The primary focus of research in the lab is studying how development has influenced the evolution of morphology in the mammalian limb. On this topic, the lab is currently studying the evolution and development of the bat wing, the parallel evolutionary reduction of mammalian digits, marsupial evolution and development, and the evolution of the mammalian shoulder girdle.Redirect_limb_evo.html
Genetic basis of mammalian girdle and limb development
In the lab, we also are working to identify the genes responsible for limb development and the evolution of the girdle and limb skeleton.  Along these lines, we are characterizing a novel mouse mutant with proximo-distal limb deformities, and we are performing a QTL screen and subsequent developmental analysis to identify the genes responsible for girdle development and evolution in mammals. Genetics.html
Biomedical research
In collaboration with researchers from several institutions, we are working on a series of applied biomedical projects (in addition to the medically-relevant QTL and mouse mutant studies outlined above). Specifically, we are characterizing development of the pig dewclaw in the hopes of developing the pig as a model for human digit regeneration, and we are studying the development of the skin membrane in newborn marsupials.Biomedical.html
HomeHome.html
Lab MembersLab_Members.html
Research
PublicationsPublications.html
TeachingTeaching.html
Lab positionsLab_Members.html