Selected Publications
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Current Publication:
De Arcanelis V, Soto D, Xiang Y (2008). Phosphodiesterase 4 and
phosphotase 2A differentially regulate cAMP/PKA signaling for
cardiac myocyte contraction under stimulation of beta1 adrenergic
receptor. Mol Pharmacol (accepted)
Wang Y, De
Arcagelis V, Ramali, B, Jung YS, Xiang Y. (2008)
Norepinephrine and epinephrine induced distinct
b2 adrenoceptor
signaling is dictated by GRK phosphorylation in cardiomyocytes. J Biol. Chem.
Jan 25; 283(4):1799-1807[Download]
Wang Y,
Lauffer B, Von Zastrow M, Kobilka B, Xiang Y. (2007) NSF
Regulates {beta}2 Adrenoceptors Trafficking and Signaling in
Cardiomyocytes. Mol
Pharmacol. May 17; 72(2):429-439
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Shcherbakova OG, Hurt CM, Xiang Y, Dell'Acqua ML, Zhang Q, Tsien RW,
Kobilka BK.(2007)
Organization of beta-adrenoceptor signaling compartments by
sympathetic innervation of cardiac myocytes. J Cell Biol. Feb 12;176(4):521-33.
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Sun Y., Huang J., Xiang Y., Bastepe M., Juppner H., Kobilka B.K., Zhang J.J., and Huang X.,
(2007) Dosage-dependent switch from G
protein-coupled to G protein-independent signaling by a GPCR. The
EMBO Journal, 26(1):53-64
Download.
Previous Publication (during Dr. Xiang's
postdoc in Stanford University):
Xiang, Y., Naro, F., Zoudilova, M., Jin, S.L, Conti, M., and Kobilka, B.K. PDE4D is
required for Beta2AR subtype-specific signaling in cardiac myocytes. Proc Natl Acad
Sci U S A, 2005. 102(3): p. 909-14. Download
Swaminath, G., Xiang Y, Lee T.W, Steenhuis
J, Parnot C, and Kobilka B, Sequential
Binding of Agonists to the beta 2 Adrenoceptor: Kinetic Evidence for Intermediate
Conformational States. J Biol. Chem, 2004. 279(1): p. 686-691. Download
Xiang Y and Kobilka B, The PDZ-binding motif of the beta 2 adrenoceptor is essential for
physiologic signaling and trafficking in cardiac myocytes. PNAS, 2003. 100: p
10776-10781. Download
Xiang Y and Kobilka B, Myocyte Adrenoceptor Signaling Pathways. Science, 2003.
300: p 1530-1532. Download
Xiang, Y., Rybin, V.O., S. Steinberg, S.S. and Kobilka, B.K. Caveolar localization
dictates physiologic signaling of beta2 adrenoceptors in neonatal cardiac myocytes. J.
Biol. Chem., 2002. 277(37): p. 34280-6. Download
Xiang, Y., Devic, E., and Kobilka, B.K. The PDZ binding motif of the beta1 adrenergic
receptor modulates receptor trafficking and signaling in cardiac myocytes. J.Biol.
Chem., 2002. 277(37): p. 33783-90. Download
Devic, E., Xiang, Y., Gould, D., and Kobilka, B.K. Beta adrenergic receptor
subtype-specific signaling in cardiac myoctyes from beta 1 and beta 2 adrenoceptor
knockout mice. Mol Pharmacol, 2001. 60(3):p. 577-83. Download
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for more publications from our current research, and click here for
publications from Dr. Xiang's graduate work
